Diabetic Nephropathy

Kidney biopsy is not typically performed to diagnose diabetic glomerulosclerosis, particularly if diabetic retinopathy is present. Detection of microalbuminuria indicates incipient nephropathy. Quantification of proteinuria allows surveillance and identifies progression, with clinical albuminuria suggesting established nephropathy. Interventional clinical trials have demonstrated proteinuria to be a surrogate end point for treatment and subsequent reduction of renal

The Impact of Diabetic Renal Disease Diabetes mellitus (DM) remains the most common primary cause of incident and prevalent chronic kidney disease (CKD) requiring renal replacement therapy in the United States and the emerging world. In the United States, more than 43% of the new CKD diagnoses in 2004 were attributable to diabetes: a total