Role Of Incretins Insulin Secretion
Exenatide At present, exenatide is the only incretin mimetic which has been approved by the US Food and Drug Administration and European Medicines Agency . Liraglutide has been approved by the EMEA, but was under review by the FDA at the time. The vast majority of published clinical data on incretin mimetics have focused
It is generally accepted that two key pathophysiological defects contribute to the metabolic irregularities observed in T2DM: first, progressive β-cell dysfunction with associated insulin secretory deficits; and second, peripheral insulin resistance. Both defects play a fundamental role in the chronic progression of hyperglycemia and both are targets of therapeutic intervention.
Before considering the mechanisms of action underlying incretin-induced insulin secretion, it is important to understand the basic cellular physiology underlying glucose-induced insulin secretion in β-cells. The details of the regulation of insulin secretion by glucose. Briefly, glucose enters β-cells via facilitated transport (Glut transporters), where it is metabolized, and adenosine triphosphate (ATP) is generated. The
Overview of Glucose Regulation and Insulin Secretion The maintenance of the plasma glucose concentration is a critical bodily function. Hyperglycemia is associated with long-term micro- and macrovascular complications, while hypoglycemia can lead to serious injury to the brain, which is dependent on plasma glucose as a fuel source. At any given time the body’s plasma